Effect of clopidogrel discontinuation at 1 year after drug eluting stent placement on soluble CD40L, P-selectin and C-reactive protein levels: DECADES (Discontinuation Effect of Clopidogrel After Drug Eluting Stent): a multicenter, open-label study I just had a 1 DES on 5 nov 2015, and i am on combo therapy Aspirin n plavix/clopidogrel after d stent. I had a recent eye bleeding on my left eye on 28 march 2016. Suspected from d combo medication for heart. They stopped d aspirin till today but recently they have advised to restart d aspirin but i am worried of d risk of bleeding. So this time after the year was up I did not stop the plavix from fear of another attack.so I weaned myself off plavix for the next 5 years to be safe.from a 3/4 pill to 1/2 a pill to a 1/4 pill for last 2 years. So, after four years and now two more heart attacks I am still taking Plavix. Since I cannot tolerate aspirin I will be on Plavix forever, I assume. I believe the usual treatment is Plavix for one year after a heart attack then just take a daily aspirin. A 1996 Lancet study 4 comparing Plavix versus aspirin for the prevention of ischaemic events, involving more than 19,000 people followed from one to three years, found that: .an intention-to-treat analysis showed that patients treated with clopidogrel had an annual 5.32% risk of ischaemic stroke, myocardial infarction, or vascular death compared with 5.83% with aspirin. My dad had a TIA about 5 years ago and was put on Plavix in the ER My question is just recently he had gone to a cardiologist to see about stopping The Plavix. The doctor told him to go ahead and stop but to take a low dose aspirin in place of it. Feb. 5, 2008 -- Heart attack survivors and other heart patients may be more likely to die or suffer a heart attack in the first three months after stopping the drug Plavix, new research shows. I had been on Plavix for a period of approximately 5 years. The Plavix was prescribed for me by another physician after having several surgeries on my Femoral Arteries. The last surgery was for the placement of stents in both Femoral's. Prior to this I had a Aortal/Femoral bypass in '95. TUESDAY, Feb. 5 (HealthDay News) -- New research finds that the first three months after heart patients stop taking the clot-preventing drug Plavix are the most dangerous. Dec. 5, 2006 -- The blood thinner Plavix may reduce the rare but deadly risks of drug-coated stents, but major questions remain, according to new research.